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Italy’s ReiThera Covid vaccine shows strong immune response in trials

Italy's hopes of producing its own Covid-19 vaccine were boosted this week as ReiThera reported a strong immune response and no serious side effects in second-stage clinical trials.

Italy’s ReiThera Covid vaccine shows strong immune response in trials
Photo: Marco Bertorello/AFP

The ReiThera vaccine, called GRAd-COV2, produced an antibody response in over 93% of volunteers three weeks after the first dose, reaching 99% after the second shot, the company based in Castel Romano near Rome said in a statement on Monday.

ReiThera stated that the results “confirmed what was already observed during Phase 1: the vaccine is well tolerated in the first dose and even better tolerated after the second.”

READ ALSO: Covid-19: How many people in Italy still aren’t vaccinated?

“Adverse events, for the most part of a small or moderate entity and of short duration, are mainly referable to pain and tension at the site of the injection, sense of fatigue, muscular pain and headache”, the company went on to say.

“No serious adverse events that could be connected to the vaccine were registered”, it said.

The study, which began on March 18th in 24 clinical centers across Italy, involved 917 volunteers, the company said.

The volunteers were divided at random into three groups, receiving either a single vaccine dose followed by a placebo dose, or two vaccine doses, or two doses of placebo, with a three-week interval in between.

ReiThera said two independent advisory boards had recommended advancing the vaccine into the third and final phase of trials, but it was unclear how this may be funded.

The company would need at least 60 million euros ($71 million) for the third phase of studies, but an Italian state audit court recently rejected plans to give it public funding, Reuters reported.

ReiThera has held preliminary talks about potentially supplying its vaccine to the European Union, which is looking to boost its own production of vaccines.

Italy’s coronavirus special commissioner said this week that a higher rate of vaccinations is needed in a new “push” to increase coverage, particularly of people in older, more vulnerable age groups.

The country is currently administering around half a million Covid-19 vaccine doses per day.

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HEALTH

Italy’s schools warned to ‘avoid gatherings’ as Covid cases rise

As Italy’s new school year began, masks and hand sanitiser were distributed in schools and staff were asked to prevent gatherings to help stem an increase in Covid infections.

Italy’s schools warned to ‘avoid gatherings’ as Covid cases rise

Pupils returned to school in many parts of Italy on Monday and authorities said they were distributing masks and hand sanitiser amid a post-summer increase in the number of recorded cases of Covid–19.

“The advice coming from principals, teachers and janitors is to avoid gatherings of students, especially in these first days of school,” Mario Rusconi, head of Italy’s Principals’ Association, told Rai news on Monday.

He added that local authorities in many areas were distributing masks and hand sanitizer to schools who had requested them.

“The use of personal protective equipment is recommended for teachers and students who are vulnerable,” he said, confirming that “use is not mandatory.”

A previous requirement for students to wear masks in the classroom was scrapped at the beginning of the last academic year.

Walter Ricciardi, former president of the Higher Health Institute (ISS), told Italy’s La Stampa newspaper on Monday that the return to school brings the risk of increased Covid infections.

Ricciardi described the health ministry’s current guidelines for schools as “insufficient” and said they were “based on politics rather than scientific criteria.”

READ ALSO:

Recorded cases of Covid have increased in most Italian regions over the past three weeks, along with rates of hospitalisation and admittance to intensive care, as much of the country returns to school and work following the summer holidays.

Altogether, Italy recorded 21,309 new cases in the last week, an increase of 44 percent compared to the 14,863 seen the week before.

While the World Health Organisation said in May that Covid was no longer a “global health emergency,” and doctors say currently circulating strains of the virus in Italy are not a cause for alarm, there are concerns about the impact on elderly and clinically vulnerable people with Italy’s autumn Covid booster campaign yet to begin.

“We have new variants that we are monitoring but none seem more worrying than usual,” stated Fabrizio Maggi, director of the Virology and Biosafety Laboratories Unit of the Lazzaro Spallanzani Institute for Infectious Diseases in Rome

He said “vaccination coverage and hybrid immunity can only translate into a milder disease in young and healthy people,” but added that “vaccinating the elderly and vulnerable continues to be important.”

Updated vaccines protecting against both flu and Covid are expected to arrive in Italy at the beginning of October, and the vaccination campaign will begin at the end of October, Rai reported.

Amid the increase in new cases, Italy’s health ministry last week issued a circular mandating Covid testing on arrival at hospital for patients with symptoms.

Find more information about Italy’s current Covid-19 situation and vaccination campaign on the Italian health ministry’s website (available in English).

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