The health ministry in Germany's southern Bavaria region said in an evening statement that it had detected a further three cases, following that of a 33-year-old German man announced earlier in the day.

“These patients are all employees of the company in the Starnberg district where the first person affected worked,” the health ministry said.

READ ALSO: Coronavirus in Germany: What you need to know

The ministry added that 40 other employees at car parts supplier Webasto had been identified as having been in “close contact” with the first patient, and they will be screened on Wednesday.

All four patients are staying in an isolation ward at a Munich hospital.

Germany's first confirmed patient, the 33-year-old man, fell ill after attending a training session hosted by a visiting Chinese colleague on January 21st.

Unlike other patients of the viral outbreak in Europe so far, the man contracted the disease without having been to China himself.

A spokeswoman for the Robert Koch Institute, Germany's centre for disease prevention and control, told AFP the German case appeared to be the first instance of a “human-to-human transmission” outside Asia.

Japan has also reported a patient testing positive for the strain of coronavirus without having travelled to China.

In Vietnam, a man visiting from Wuhan is suspected of infecting his son who had been living in Ho Chi Minh City for four months.

The Chinese woman who held the training session in Germany “started to feel sick on the flight home on January 23”, Andreas Zapf, head of the Bavarian State Office for Health and Food Safety, told a press conference.

She immediately sought medical attention on her return and was confirmed to have caught the virus, which has spread rapidly in recent weeks after first emerging in the Chinese city of Wuhan.

The woman had recently visited her parents in the Wuhan region, Zapf said.

In a statement, the Webasto company said it had halted all business travel to and from China “for at least the next two weeks”.

The virus has so far killed over 100 people and infected more than 4,500 people in China.

Cases have also been reported in a string of other countries, including the United States, France, Australia and Japan.