The veteran footballer declared on his Instagram account that he has already played on one leg before.
The 35-year-old – whose 28 goals have largely helped Manchester United compete for a Champions League spot next season as well as landing the League Cup – suffered serious knee ligament damage in last Thursday's Europa League win over Anderlecht.
Ibrahimovic, who has defied the doubters since his move last summer from Paris Saint-Germain, posted on Instagram a picture of the knee and a defiant message to those who had suggested his career was over.
“First of all, thank you for all the support and love,” read his message.
“It's no news I got injured so I will be out of football for a while.”
“I will go through this like everything else and come back even stronger. So far I played with one leg so it shouldn't be any problem.”
“One thing is for sure, I decide when it's time to stop and nothing else. Giving up is not an option. See you soon.”
Manchester United performed well enough without him on Sunday beating Burnley 2-0 with French forward Anthony Martial and veteran Wayne Rooney scoring.
Victory put United just a point behind fourth-placed Manchester City – who occupy the last Champions League spot – and adding further spice to Thursday's Manchester derby.