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HEALTH

French health regulator recommends AstraZeneca’s Covid vaccine for under-65s only

France's top health authority has approved the AstraZeneca vaccine for use on 18 to 65-year-olds only, following the lead of several other European countries who say there is not enough data to show its effectiveness on over 65s.

French health regulator recommends AstraZeneca's Covid vaccine for under-65s only
The AstraZeneca vaccine. Photo: AFP

The European Medicines Agency has licenced the AstraZeneca vaccine for use on all age groups, but health regulators in Germany, Sweden and Austria have cleared it only for 18-65-years old, saying there is not enough data to prove its efficiency for the over 65s.

The French medical body Haute Autorité de santé on Tuesday followed their lead, recommending it only for under 65s.

French President Emmanuel Macron was on Tuesday evening holding an emergency meeting with vaccine producers and laboratories in France.

The object of the meeting was to “take stock of the current state of vaccine production capacity” at the French and European levels and to “call for this capacity to be maximised in the short term” in order to “increase it rapidly and significantly”, the president's office said.

The meeting was attended by France's health minister, industry minister and director general of public health, along with the European Commission's health chief Sandra Gallina by video link.

The French pharma giant Sanofi has already announced that it will produce an extra 125 million doses of the Pfizer vaccine, since its own vaccine will not be ready for the market for many months yet. 

It comes as the European Commission indicated that it is shifting its early Covid-19 vaccination strategy away from AstraZeneca after the Anglo-Swedish company fell far short in its delivery of doses.

Gallina told MEPs the firm has been able to guarantee just 25 percent of the more than 100 million doses promised and that this was “a real issue” for the EU's 27 countries.

“AstraZeneca was going to be the mass vaccine for quarter one,” she said, referring to the first three months of 2021. “The fact that AstraZeneca is not there in the quantities that were stipulated in the contract is quite problematic for all member states.”

Gallina added that the Commission was now looking to the vaccines made by BioNTech/Pfizer and Johnson & Johnson to fill the gap.

France had based its vaccine strategy largely on the Pfizer BioNTech and Moderna vaccines for January and February.

Unlike the Pfizer BioNTech vaccine which must be stored at -70C, the AstraZeneca one can be stored at between 4C and 8C and is therefore easier to administer in the community.

The French government has given the go-ahead for pharmacies to begin offering the AstraZeneca, vaccine, with the first doses expected to be available in pharmacies by the third week of February.

French pharmacies already offer vaccines including the flu vaccine, although the Covid jab is expected to be on an appointment basis within the priority group timetables, which place the most vulnerable at the front of the queue.

The French government has been the subject of much criticism for its slow start to the vaccine programme, although this has picked up speed in recent weeks and now 1.4 million people have received the injection.

 

France has decided not to delay the second dose of the vaccine and is sticking with the manufacturer's recommendation of 3-4 weeks between the first and second dose – a feared shortage of doses lead to some first-dose appointments being cancelled last week.

However even with the increased pace of the vaccination campaign, France is still lagging well behind many other European countries.

 

Health minister Olivier Véran has said that everyone who wants the vaccine will have it by the end of August, but supply problems with the AstraZeneca vaccine have lead to France's February target of 4 million people vaccinated being downgraded to “between 2.5 million and 4 million” people.

At present the vaccine programme is France is only to four groups; over 75s, people under 75 with serious health conditions, healthcare workers over 50 or with a health conditions and residents and staff in the country's Ehpad nursing homes.

The next two groups – 65-74-year-olds and all healthcare workers – are expected in February but no date has yet been set for this.

Anyone who is in a priority group can book an appointment direct.

READ ALSO How to book an appointment for the Covid vaccine in France

Member comments

  1. I hope Macron has agreed to this. His well known expertise in all matters medical is valuable.(Not)
    Sanofi screwed up so they are having to produce Pfizer’s vaccine Quel honte!

  2. Latest studies from the USA show that the UK is absolutely right in its rollout of this drug and that Franc has got this badly wrong. As someone over 65 I hope France gets up to date on this asap.I would also point out that 5 million EU citizens resident in the UK will be getting vaccinated according to UK protocols. Is France saying any EU citizens in Britain over 65 should not accept an AZ vaccination ?

  3. What the story is saying is that it’s not RECOMMENDED for over 65s ( not withstanding it’s not for any children, pregnant or lactating women and certain other medically compromised people). It then talks about the 65-74 age cohort being vaccinated- so the government is STILL vaccinating these people AGAINST HEALTH recommendation? I would go with the experts advice, its there for a REASON.

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HEALTH

How serious is the threat from dengue fever in France?

As tiger mosquitoes are now present in over 80 percent of mainland France, health authorities are worried that local transmission of tropical diseases, like dengue fever, will increase.

How serious is the threat from dengue fever in France?

As of January 2024, tiger mosquitoes – known for their ability to carry diseases such as dengue, chikungunya and Zika virus – had been detected in 78 of France’s 96 mainland départements, including the Paris region.

This has left public health authorities concerned about the spread of dengue fever in France, particularly this summer as large crowds are expected amid the Olympic Games.

READ MORE: MAP: Tiger mosquitoes reach northern France

How common is dengue fever in France?

In the first four months of 2024, 1,679 cases of dengue fever were identified in mainland France, a number that is 13 times higher than the same period last year, Le Parisien reported.

Crucially, however, none of these are believed to have been contracted in mainland France – they were all reported among patients who had recently travelled from the tropical regions where dengue fever is common.

The majority of cases were from people who had visited the Caribbean islands of Martinique and Guadeloupe – where the disease is endemic.

These islands are for administrative purposes part of France – so often show up in French health data – but they are roughly 7,000km away from Paris.

So far, there have not been any indigenous cases (autochtone – or people infected on mainland French soil) yet this year.

Local transmission of the disease remains relatively rare. In 2023, nine separate outbreaks of indigenous dengue transmission were identified, one of which occurred in the Paris region. These led to 45 cases of local transmission (in mainland France).

Most were in southern France – in the Provence-Alpes-Côte d’Azur, Occitanie and Auvergne-Rhône-Alpes regions – though one outbreak occurred in the Paris region, according to French public health authorities.

This is less than 2022, which was a notable year with 66 total cases of indigenous dengue fever were recorded. In comparison, between 2010 and 2021, only 48 cases (total) were recorded.

What to expect for 2024

Experts believe that the number of cases in France, including indigenous ones, will grow this year, as tiger mosquitoes now occupy more territory in mainland France.

On top of that, the number of cases has increased significantly in Martinique and Guadeloupe.

“What we see in France is a mirror image of what is happening in the French Caribbean, and more widely in Latin America and the rest of the Caribbean, where dengue fever has been circulating since the start of the year at unprecedented levels”, the head of Santé Publique France, Dr Caroline Semaille, said during a press conference.

The Olympic Games will also bring an influx of tourists from all over the world, and weather conditions are expected to be conducive to mosquitoes – a year with a lot of rainfall, and potentially high temperatures. 

What is dengue fever?

The disease is spread to people from bites by infected mosquitoes.

The most common symptoms are high fever, chills, abdominal, joint and muscle pains, and vomiting. It can also cause a skin rash that resembles measles, according to France’s Institut Pasteur.

Symptoms usually begin three to 14 days (with an average of four to seven) after being bitten.

However people are asymptomatic in 50 to 90 percent of cases (depending on the epidemic), which can make monitoring difficult.

At-risk groups include the immunocompromised, children and the elderly, who are more likely to suffer from severe forms of the disease.

Deaths from the disease are very rare, occurring in around 0.01 percent of all cases, almost all in countries that have poor healthcare systems.

How can I avoid tiger mosquitoes?

Female tiger mosquitoes lay their eggs in water, and they can lay several hundred eggs at once. Therefore try to avoid having any standing water outside your home and be aware of the items that might collect rainwater.

This includes regularly emptying vases, flower pots, as well as watering cans and pots. If you want to collect rainwater, you could cover water butts with mosquito nets or fabric to keep the mosquitoes from getting inside.

READ ALSO 5 plants that (allegedly) repel mosquitoes

You can also keep your gutters clean – this helps to keep the water flowing when it rains, and it avoids any stagnant pools from building up.

To protect yourself, try to wear long, loose and light-coloured clothing, in addition to insect repellent. You might also consider wearing a mosquito net head gear.

The main difference between tiger mosquitoes and other species would be getting a bite during the day, and the fact that tiger mosquitoes are likely to bite several times. You can tell for sure if it was a tiger mosquito by seeing the insect itself. They are also silent.

There is no immediate cause for alarm if you are bitten, in almost all cases the bites are just itchy and annoying. In very rare cases, tropical diseases can be spread by the mosquitoes – seek medical help if you develop a high fever and rash.

READ MORE: How to prevent the spread of tiger mosquitoes in France

What do tiger mosquitoes look like?

They are very small, about 5 mm, and they have a highly contrasting colour, with black and white stripes on their body and legs.

If you believe you have spotted a tiger mosquito, you can report it to public health authorities online.

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