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EXPLAINED: What is the new Swiss coronavirus drug and how does it work?

While the focus in Switzerland, and elsewhere, has been primarily on vaccines in the past few months, a new medication may also offer hope in the fight against Covid-19. This is what we know about this drug.

EXPLAINED: What is the new Swiss coronavirus drug and how does it work?
Swiss pharma company Roche has good results from its new anti-Covid drug. Photo by SEBASTIEN BOZON / AFP

The Swiss government signed a contract with local pharmaceutical company Roche on Tuesday to purchase a “promising drug” to treat coronavirus.

The government bought the medication, which Roche developed jointly with a US biotech firm Regeneron, after recent clinical trials showed that it not only treats but also helps prevent Covid infections. 

What exactly is this drug and how does it work?

In technical terms, it is the combination of the antibodies casirivimab and imdevimab.

To put it simply, “clinical trials show that these treatments provide effective protection against severe forms of the disease”, the Federal Office of Public Health (FOPH) said in a statement.

For instance, study findings indicate that people who took this drug during clinical trials saw their risk of symptomatic infection reduced by 81 percent, and their symptoms cleared within one week.

READ MORE: Swiss-American antibody drug ‘effective at preventing Covid infection’

What’s the difference between Covid vaccines and this new medication?

Vaccines are given to prevent coronavirus infections and stop the spread and outbreaks of the disease.

The antibody drug, on the other hand, treats patients who were already contaminated, by “neutralising” the virus, FOPH said.

Has this med been approved for use in Switzerland?

No. However, the drugs that have not yet been authorised “can be prescribed in exceptional cases”, FOPH said

It added that Switzerland’s Covid-19 legislation “provides for exceptions to the traditional authorisation procedure, provided that the drug in question prevents and treats COVID-19 based on available data”. 

Even though this medication is still experimental at this point, “the federal government will cover the costs of these treatments until they are reimbursed by compulsory health insurance”, according to FOPH.

For its part, the regulatory body Swissmedic said that “it gave the go-ahead for the distribution. As a result, this medicinal product is available even before the authorisation decision has been taken”.  

How many doses did Switzerland buy and when will they be available?

The initial purchase is 3,000 doses. The government did not reveal how much it spent to buy them.

It did say, however, that they will be available from mid-May “for certain groups of high-risk patients”.

Are there other promising coronavirus treatments on the horizon in Switzerland?

In August 2020, Swiss authorities signed a “reservation agreement” for the delivery of 200,000 doses of a possible new coronavirus medication. 

If the yet-unnamed drug successfully passes clinical trials and is approved for the market, Switzerland will receive priority access, the Federal Office of Public Health (FOPH) said. 

The government also secured the right to be supplied with up to 3 million further doses.

Manufactured by a Swiss company, Molecular Partners, a spin-off of the University of Zurich, the new drug acts as an “immunotherapeutic agent”. 

At this point it is still under development.

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COVID-19

What does the increase in the number of Covid cases in Switzerland mean?

Coronavirus infections are on the rise again, with Swiss health officials and epidemiologists expressing concern over the possible evolution of the disease.

What does the increase in the number of Covid cases in Switzerland mean?

While the worst of the Covid pandemic is long over, and experts don’t expect it to re-emerge with the same strength and health consequences as it had in 2020, new cases have been reported in the past weeks.

Wastewater analysis, one of the means employed by health officials to measure the presence of coronavirus, indicates a viral load that is at least five times higher than usual, with values “now almost as high as in some previous Omicron-related waves,” Christoph Ort, spokesperson for Eawag Institute, which traces Covid viruses in 14 wastewater treatment plants in Switzerland, told the media.

What does this mean?

According to Federal Office of Public Health (FOPH), the most common sub-variant in Switzerland right now is the highly transmissible XBB, also known as ‘Kraken.’

The Eris and Pirola variants, which circulated in the summer and early fall are also still present.

While none is nearly as dangerous (at least for most people) as the early Alpha and Delta viruses, which claimed hundreds of thousands of lives in the early stages of the pandemic, there is a reason for concern nevertheless.

“It’s a start of a small wave,” said Rudolf Hauri, head of the Cantonal Doctors’ Association.

“More people are being admitted to hospitals again with, or because of, coronavirus. There are also new cases in intensive care units, but these are generally people with a medical history.”

Should you be worried?
 
While the number of people with serious Covid-related complications is not expected to be as high as previously, the rise in the number of infections should not be trivialised either, infectious disease specialists say.
 
This is especially important for people in the high-risk category — those over 65 or suffering from chronic illnesses — who can get quite sick if infected with the new variants, according to FOPH.
 
This is all the more important as the flu season is about to begin in Switzerland as well, and the confluence of both illnesses, plus other respiratory viruses that typically circulate during the winter, can be very risky.
 
What can you do to protect yourself?
 
Other than adopting the same protective measures as those during the pandemic — that is, washing hands, avoiding close contacts and crowded spaces, and wearing masks where needed — health officials also recommend top-up shots, for both Covid and flu.

READ ALSO: Who should get top-up Covid and flu jabs in Switzerland?

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