SHARE
COPY LINK

IAEA

Technology helps Ebola diagnosis in West Africa

The UN nuclear agency said Tuesday that it will provide specialised equipment to West African countries hit by the Ebola outbreak to help faster diagnosis.

Technology helps Ebola diagnosis in West Africa
RT-PCR machine from Bio Rad, similar to the proposed system. Photo: Bio Rad

The International Atomic Energy Agency will send to Sierra Leone "in the coming weeks" a machine using the so-called Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) technology.

RT-PCR allows the Ebola virus "to be detected within a few hours, while other methods require growing on a cell culture for several days before a diagnosis is determined," the IAEA said.

"Early diagnosis … if combined with appropriate medical care, increases the victims' chance of survival and helps curtail the spread of the disease by making it possible to isolate and treat the patients earlier," it said in a statement.

In addition, the Vienna-based body will ship out cooling systems, biosecurity equipment, diagnostic kits and other materials. Similar support will be provided to Liberia and Guinea, it said.

Sierra Leone and other affected countries are already applying RT-PCR, but their capability is limited due to shortages of diagnostic kits and other materials.

The method, co-developed with the UN Food and Agriculture Organization (FAO), was instrumental in the global eradication of rinderpest, long a scourge of livestock.

RT-PCR initially used radioactive isotopes to determine the presence of a virus but subsequent refining of the process has led to the use of fluorescent markers instead.

The Ebola epidemic has killed more than 4,400 people this year, mostly in Guinea, Sierra Leone and Liberia, prompting the World Health Organization (WHO) to brand it "the most severe acute public health emergency in modern times".

Member comments

Log in here to leave a comment.
Become a Member to leave a comment.

EBOLA

Spanish researchers develop five-strain vaccine against lethal Ebola virus

Spanish researchers are working on a vaccine against all five strains of the killer Ebola virus in what would be a world first, Madrid's October 12 Hospital said Wednesday (July 11).

Spanish researchers develop five-strain vaccine against lethal Ebola virus
Ebola protects itself with proteins that act as a shield, and only exposes its vulnerable zones for short periods of time. Photo: AFP

A prototype vaccine developed by pharmaceutical group Merck is already in use, but acts only against the most virulent, “Zaire” strain.

Despite not having market approval, Merck's rVSV-ZEBOV was administered to people in the Democratic Republic of Congo in May, with UN approval, in a bid to contain an outbreak of the same virus that killed more than 11,300 in three West African countries from 2013 to 2015, sparking international panic.

For several months, a team from the October 12 Hospital has been working with researchers at two other hospitals in the capital to examine and learn from blood samples taken from three people cured of Ebola in Spain.

Lead researcher Rafael Delgado told reporters the difficulty lay in the fact that the virus protects itself with proteins that act as a shield, and only exposes its vulnerable zones for short periods of time.

That makes it tough for the body's immune system to fight the virus.

The three Spanish patients had produced “very effective” viral antibodies, though in a “small quantity” and only against the Zaire strain they were contaminated with.

Delgado, head of microbiology at the hospital, said researchers are aiming to reproduce these antibodies on a larger scale, and in a way that would make them efficient against all five virus strains.

US medical giant Johnson & Johnson is separately developing an experimental vaccine against two Ebola strains.

Delgado said researchers hope to get results from mouse experiments within a year.

The Ebola epidemic caused alarm in Spain in 2014 when a nursing assistant, Teresa Romero, became the first person infected outside Africa.

She caught the disease while tending to a Spanish missionary repatriated from Sierra Leone, who died in Spain in September that year.